Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril
نویسندگان
چکیده
منابع مشابه
Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril.
BACKGROUND AND OBJECTIVE A single dose of 10 Gy radiation to the thorax of rats results in decreased total lung angiotensin-converting enzyme (ACE) activity, pulmonary artery distensibility and distal vascular density while increasing pulmonary vascular resistance (PVR) at 2 months post-exposure. In this study, we evaluate the potential of a renin-angiotensin system (RAS) modulator, the ACE inh...
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Our goal is to develop countermeasures for pulmonary injury following unpredictable events such as radiological terrorism or nuclear accidents. We have previously demonstrated that captopril, an angiotensin converting enzyme (ACE) inhibitor, is more effective than losartan, an angiotensin type-1 receptor blocker, in mitigating radiation-pneumopathy in a relevant rodent model. In the current stu...
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ژورنال
عنوان ژورنال: Respirology
سال: 2012
ISSN: 1323-7799
DOI: 10.1111/j.1440-1843.2012.02247.x